Cisplatin mitophagy

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August undefined, 2024

WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of mitochondrial quality control mechanism that degrades damaged mitochondria and maintains cellular homeostasis. WebOct 5, 2024 · Mitophagy refers to the selective self-elimination of mitochondria under damaged or certain developmental conditions. As an important regulatory mechanism to remove damaged mitochondria and maintain the internal and external cellular balance, mitophagy plays pivotal roles in carcinogenesis and progression as well as treatment. …

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WebBackground and Objectives: Combination therapy improves the effect of chemotherapy on tumor cells. Magnolol, used in treating gastrointestinal disorders, has been shown to have anti-cancer properties. We investigated the synergistic effect of cisplatin and magnolol on the viability and maintenance of MKN-45 gastric cancer cells. Materials and Methods: … WebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … flank steak house hutchinson

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WebScience topic Sirtuin 1. A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in ... WebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of … WebThe results revealed that cisplatin‑resistant A549 cells contained high levels of APE1, and exhibited elevated levels of autophagy. The levels of m‑APE1 and t‑APE1 protein were increased in the A549/DDP cells when compared with these levels in the A549 cells. flank steakhouse new brighton

Mitophagy Impairment Aggravates Cisplatin-Induced Ototoxicity

Cisplatin vs Mitomycin Comparison - Drugs.com

WebOct 12, 2024 · Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin-induced cisplatin … WebAug 7, 2024 · Mitophagy, a term first proposed by Lemasters (2005), refers to a process by which mitochondria are selectively degraded by autophagy ( Palikaras et al., 2024 ), which has emerged as an important mechanism of mitochondrial quality and quantity control ( Pickles et al., 2024 ). can roommates have seperate renters insuranceWebMar 28, 2024 · Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is increasing evidence that mitochondrial dysfunction plays an … flank steak house hutchinson mn

"WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. ... Cisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and ... " - Cisplatin mitophagy

Cisplatin mitophagy

Autophagy regulates cisplatin-induced stemness and ... - PubMed

WebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of … WebMar 28, 2024 · Although mitophagy is considered of particular importance in protecting against AKI, little is known of the precise role of mitophagy and its molecular mechanisms during cisplatin-induced nephrotoxicity. Also, evidence that activation of mitophagy improved mitochondrial function is lacking.

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WebThe role of autophagy/mitophagy was investigated by transient transfection of siATG14, GFP-LC3, tF-LC3, mKeima-Red-Mito7 and Western blot analysis of autophagic and mitochondrial proteins. Results: In vitro and OSCC tissue double labelling confirmed that CD44+cells co-expresses ABCB1 and ADAM17. WebNov 1, 2024 · Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal tubular cells. Mitophagy is a form of selective autophagy that removes damaged or dysfunctional mitochondria to maintain cellular homeostasis.

WebNov 5, 2024 · While cisplatin induced a severe mitophagy defect, mitolysosomes represented by the mCherry signal were markedly higher in Casp9 HZ renal tubule cells exposed to cisplatin (Fig. 6A). Cisplatin induced marked mitochondrial depolarization in kidney tubule cells, which was ameliorated in Casp9 HZ renal tubule cells ( Fig. 6B ). WebMar 7, 2024 · Recently, some authors believed that miR34a and mitophagy played a role in age-related and drug-induced hearing loss. Our study aimed to explore the involvement of miR-34a/DRP-1-mediated mitophagy in cisplatin-induced ototoxicity. Methods: In this study, C57BL/6 mice and HEI-OC1 cells were treated with cisplatin.

WebOct 7, 2024 · Chaetomugilin J Inhibits Mitophagy Induced by Cisplatin. Mitophagy is a type of autophagy that eliminates redundant or damaged mitochondria. 26 It plays an important role in mitochondrial function. The expression of pink1 and parkin, which are mitophagy-related proteins, were detected to reflect mitophagy. WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice.

WebBackground: To study the protective effect of berberine (BBR) on cisplatin-induced acute kidney injury (AKI) and its effect on mitophagy. Methods: (I) Male C57BL/6 mice aged 6-8 weeks were randomly divided into control group (saline), cisplatin group (cisplatin), and cisplatin + BBR (5, 10 mg/kg) groups.

WebMar 15, 2024 · It has been found that PNS is able to alleviate cisplatin-induced nephrotoxicity by inducing BNIP3-mediated mitophagy via hypoxia-inducible factor-1α (HIF-1α). PNS treatment restores renal function via attenuating the accumulation of injury mitochondria and cell apoptosis in TECs ( Liang et al., 2024 ; Li et al., 2024c ). can roosters be gayWebOct 6, 2024 · PDF On Oct 6, 2024, Veronica Cocetta and others published BNIP3-dependent mitophagy role in cisplatin resistance Find, read and cite all the research you need on ResearchGate can root 6 be simplifiedWebNov 1, 2024 · Abstract. Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal … can roosters eat layer pelletsWebSep 25, 2024 · Meanwhile, mitophagy indicated by autophagosome formation and LC3B-II accumulation was also attenuated in PINK1 knockout rats. Renal expression of PINK1 and Parkin were down-regulated while BNIP3L was up-regulated by cisplatin treatment, indicating a major role of BNIP3/BNIP3L pathway in cisplatin-induced mitophagy. can roosters mate with their offspringWebMay 20, 2024 · Cisplatin ototoxicity is associated with cochlear cell oxidative stress and mitochondrial damage. However, mitophagy is vital for maintaining mitochondrial quality and cellular metabolism. Accordingly, we investigated the role of mitophagy in regulating cisplatin-induced ototoxicity using the auditory cell line HEI-OC1. can roosters be silencedWebNational Center for Biotechnology Information can roosters eat laying feedWebCisplatin is a widely used chemotherapeutic agent. Here we show that cisplatin induces apoptosis in renal collecting duct-derived cells (MDCK-C7 cells, resembling principal … can root access all files