WebJun 1, 2024 · Dexrazoxane for injection, a cardioprotective agent for use in conjunction with doxorubicin, is a sterile, pyrogen-free lyophilizate … WebAug 22, 2024 · Administer in a dosage ratio relative to the IV dose of doxorubicin hydrochloride. Adults Prophylaxis of Anthracycline-induced Cardiomyopathy IV. Recommended dosage ratio of dexrazoxane to doxorubicin is 10:1 (e.g., 500 mg/m 2 dexrazoxane should be administered with 50 mg/m 2 doxorubicin). Prescribing Limits …
Dexrazoxane - an overview ScienceDirect Topics
WebDexrazoxane is clinically used to reduce doxorubicin cardiotoxicity and anthracycline-induced extravasation injury. Dexrazoxane is a strong catalytic inhibitor of topoisomerase II. It can also undergo metabolism to form an iron-binding analog of EDTA. Dexrazoxane was originally thought to act by red … WebDexrazoxane (Cardioxane, Zinecard, a cyclic derivative of edetic acid, is a site-specific cardioprotective agent that effectively protects against anthracycline-induced cardiac … round stone patio table
The Role of Topoisomerase IIβ in the Mechanisms of Action of ... - PubMed
WebFor doxorubicin, use of dexrazoxane is recommended after the cumulative dose reaches 300 mg/m2 (i.e., 55% of the recommended maximum). A similar formula could be used … Dexrazoxane injection is available as 2 different products that are used to treat or prevent certain side effects that may be caused by certain chemotherapy medications. Dexrazoxane injection (Zinecard) is used to prevent or decrease heart damage caused by doxorubicin in women who are taking the medication … See more Some people who took a medication that is very similar to dexrazoxane injection developed new forms of cancer. There is not enough information to tell if receiving dexrazoxane … See more It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as … See more Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to dexrazoxane injection. Ask your doctor or pharmacist any questions you have about … See more WebCOMMON BRAND NAME (S): Zinecard. USES: Dexrazoxane is used to reduce the risk and severity of heart damage caused by doxorubicin treatment and similar cancer … strawberry jello poke cake with dream whip