• Son of sevenless (SOS1) is an important GEF in the cell growth-regulatory MAPK/ERK pathway. SOS1 binds GRB2 at the plasma membrane after EGF receptor activation. SOS1 activates the small G protein Ras. • eIF-2b is a eukaryotic initiation factor necessary to initiate protein translation. eIF-2b regenerates the GTP-bound form of eIF-2 for an additional cycle in protein synthesis initiation, i.e., its binding to the Met-t-RNA. WebFeb 27, 2024 · EXPH5 exophilin 5. EXPH5. exophilin 5. Gene ID: 23086, updated on 27-Feb-2024. Gene type: protein coding. Also known as: EBS4; SLAC2B; SLAC2-B. See all …
Seth Margolis - The Solomon H Snyder Department of Neuroscience
WebFeb 7, 2024 · Ephexin5-GFP is enriched at sites of new spine outgrowth (A) Images of dendrites from neurons (DIV 9-10) co-transfected at DIV 7-8 with E5-GFP + DsRedExpress (DsRed) and treated with bicuculline to enhance the rate of new spine outgrowth. Blue arrows indicate sites of new spine outgrowth. Time stamps are relative to time of new … it governance usa inc
EphB-Mediated Degradation of the RhoA GEF Ephexin5 Relieves a …
WebThe 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and therefore potentially oncogenic missense mutations … WebFeb 1, 2024 · Ephexin5 is a GEF that activates RhoA in neurons [122]. Intriguingly, their results also showed that the expression of Ephexin5 is increased at sites in dendrites where future new spines are ... WebThe emergence of Ephexin5 as a therapeutic target in Alzheimer’s disease. Cook EK, Sell GL, Schaffer TB, Margolis SS. Expert Opin Ther Targets. 2024 Apr;23 (4):263-265. doi: 10.1080/14728222.2024.1586884. PKCε inhibits neuronal dendritic spine development through dual phosphorylation of Ephexin5 at serine residues 107 and 109. need upholstey fabric to cover a chair rement