Myers alkylation
Both (R,R)- and (S,S)-pseudoephedrine can be used as chiral auxiliaries. Pseudoephedrine is reacted with a carboxylic acid, acid anhydride, or acyl chloride to give the corresponding amide. The α-proton of the carbonyl compound is easily deprotonated by a non-nucleophilic base to give the enolate, which can further react. The configuratio… Web概要; 羧酸衍生物→羧酸衍生物. 该反应以麻黄碱(该原料比较廉价易得)作为原料，在碱性作用下形成烯醇锂后，再与卤代烷烃进行手性烷基化反应，得到手性产物的方法。
Myers alkylation
Did you know?
WebMyers' asymmetric alkylation exhibits the following properties. Contents 1 Divisibility 2 Comparability 3 Connectivity 4 Disturbability 5 Reorderability 6 Substitutability 7 … WebAn overview of the Myers (not Meyers) Asymmetric Alkylation with a literature example. Also how to remove the pseudoephedrine auxiliary to do further chemistry.
Web1 jun. 2011 · Abstract. The first total synthesis of (−)-bitungolide E is described. The key steps include a Myers’ alkylation, modified Evans’ syn aldol-reaction, using Crimmins protocol, Sharpless ... WebEnolization-Alkylation of Pseudoephedrine Amidesa,b,c a Isolated yields. b For activating alkyl groups (allyl, benzyl) alkyl bromides were used and for nonactivating groups (ethyl, …
WebWelcome to the Myers Research Group! Learn about our research. Andrew G. Myers. Amory Houghton Professor of Chemistry... Read more about Andrew G. Myers. 12 …
Weba Myers alkylation [23] of (+)-pseudoephedrine derived amide 7 with allylic iodide 8. The initial epoxidation substrate of type 6 that we targeted possessed benzyl and TBDPS ethers as the protecting groups. First, allylic iodide 8 was synthesized by iodination of the mesylate derived from known alcohol 9 [24] (Scheme€2). Then,
Web30 aug. 2009 · Myers, A. G. et al. Pseudoephedrine as a practical chiral auxiliary for the synthesis of highly enantiomerically enriched carboxylic acids, alcohols, … mulligatawny soup mixWeb21 nov. 2014 · Myers手性烷基化反应 (Myers Asymmetric Alkylation) 2014/11/21 加成反应 手性控制, 烷基化, 麻黄碱 Author: LuWenjie 3,104views 概要 羧酸衍生物→羧酸衍生物 该反应以麻黄碱 (该原料比较廉价易得)作为原料，在碱性作用下形成烯醇锂后，再与卤代烷烃进行手性烷基化反应，得到手性产物的方法。 通过该方法可以吧麻黄碱部位转化为各种其他 … how to maximize insurance claimWebEsta reação é uma técnica útil para α-alquilação assimétrica de cetonas e aldeídos, que são intermediários sintéticos comuns para produtos naturais de interesse medicinal e outros compostos orgânicos relacionados . Esses produtos naturais incluem (-) - C10-desmetil arteanuína B, o análogo estrutural da artemisinina antimalárica , o metabólito … mulliken district library miWeb1 jun. 2000 · The key features include diastereoselective alkylation, using Myers auxiliary, for the preparation of the three carbon synthon , stereo- and regioselective oxidative vicinal functionalization of ... mullin accountantsWeb11 mei 2006 · Abstract. [reaction: see text] The enantioselective synthesis of the carbon skeleton of 6-deoxyerythronolide B has been achieved in 23 linear steps from propionaldehyde. The synthesis relies on an iterative approach employing an asymmetric acyl-thiazolidinethione propionate aldol reaction to establish eight of nine stereogenic … how to maximize intel turbo boostWeb15 aug. 2024 · Alkylation of Pseudoephenamine and Pseudoephedrine Amides; Diastereoselective Alkylation Reactions. Hydrolysis of Alkylation Products; Reduction of … mulligatawny soup recipe pioneer womanWeb1 nov. 2024 · Using Myers asymmetric alkylation protocol, the synthesis of C9–C13 segment 188 was achieved starting from chiral pseudoephedrine 191 (Scheme 27). The propionamide 191 on asymmetric alkylation followed by reductive removal of chiral auxiliary resulted in the alcohol derivative, which on Swern oxidation provided the desired … mullinalaghta lgfa twitter