WebThe fields of phototherapy and of inorganic chemotherapy both have long histories. Inorganic photoactivated chemotherapy (PACT) offers both temporal and spatial control over drug activation and has remarkable potential for the treatment of cancer.Following photoexcitation, a number of different decay pathways (both photophysical and … WebFor each indication of a photoactivated chemotherapy, we test for improvements in safety and efficacy against the repurposed drug in cells and animal models. As needed, we'll modify the formulation and correlate outcomes with fluorescent behavior in a dosimetry system to prepare a therapy that meets the FDA requirements for an IND.
Why develop photoactivated chemotherapy? - PubMed
WebOne of the two Boston facilities that provides hyperthermic intraperitoneal chemotherapy (heated chemotherapy for advanced stomach cancers) Survivorship Programs for adult … WebPhotoactivated chemotherapy is an approach where a biologically active compound is protected against interaction with the cell environment by a light-cleavable protecting … opening times asda huyton
A potent cytotoxic photoactivated platinum complex PNAS
WebObjective: This review summarizes different approaches towards photoactivated chemotherapy and identifies its challenges and opportunities. Results: The respective … WebOct 31, 2024 · This work realizes an in vitro proof‐of‐concept of the lock‐and‐kill principle, which may ultimately be used to design strategies aimed at knowing where and when light irradiation should be realized in vivo. Photosubstitutionally active ruthenium complexes show high potential as prodrugs for the photoactivated chemotherapy (PACT) treatment … WebSep 21, 2016 · My project involved design and synthesis of ruthenium and dirhodium based anticancer metallodrugs for their potential applications in Photodynamic Therapy (PDT) and Photoactivated Chemotherapy (PACT). opening times asda leigh